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Examples |
Applications |
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Obtained by Animal Immunization |
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IgG and IgM |
Detection, purification |
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Obtained by in Vitro Methods (Affinity reagents based on antibody-like proteins) |
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Fab |
Detection, purification, therapeutics |
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FV |
Detection, purfication, crystallization |
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scFV |
Detection, purfication, in vivo perturbation, therapeutics |
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Domain antibodies (VH, VL) |
Detection, purfication, therapeutics |
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VHH (shark and camel heavy-chain antibody VH domains) |
Detection, purfication |
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Fibronectin type 3 domain |
Detection, purfication, in vivo perturbation |
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Affinity Reagents Based on Other Proteins (Scaffolds) |
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Affibody (protein A) |
Detection, purfication |
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Anticalin (lipocalin) |
Detection, purfication |
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Ankyrin repeats |
Detection, purfication, in vivo perturbation |
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Thioredoxin |
In vivo perturbation |
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Affinity Reagents Based on Other Molecules |
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Conbinatorial peptides |
Detection, crystallization, in vivo perturbation |
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RNA or DNA aptamers |
Detect, purification, in vivo perturbation |
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Small chemical molecules |
In vivo perturbation |
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Genomics:GTL (formerly Genomes to Life) is a program of the
Office of Biological and
Environmental Research
of the U.S.
Department of Energy Office of Science
Base URL: http://genomicsgtl.energy.gov
Last modified: Wednesday, July 11, 2007