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Genomic Science Program

2008 Awardee

Systems Level Engineering of Plant Cell Wall Biosynthesis to Improve Biofuel Feedstock Quality

INVESTIGATORS: S.P. Hazen

INSTITUTION: University of Massachusetts Amherst

NON-TECHNICAL SUMMARY: The cell wall is a distinguishing feature of plants. It is a complex composite of polysaccharides, proteins, and lignin, with lignin and cellulose representing two of the most abundant bio-organic compounds on the planet.

OBJECTIVES: The goal of the proposed research is to 1) identify proteins that regulate biosynthetic enzymes and pathway modules of the cell wall and 2) generate a regulatory network model that enable us to manipulate whole pathways by transgenic expression of these key regulators.

APPROACH: First, we will screen for transcription factor protein interactions with regulatory sequences of key cell wall genes involved in cellulose, hemicellulose, and lignin synthesis. Second, using a recently developed method to capture and identify the DNA bound to a transcription factor protein, we will define the extent of their genomic targets. Concurrently, we will develop gain- and loss-of-function mutants in the dicot model Arabidopsis and the monocot model Brachypodium to determine the effects of these perturbations on cell wall properties and energy crop quality.

PROJECT CONTACT:
Name: Samuel P. Hazen
Phone: 858-204-3902
Email: hazen@bio.umass.edu

 

Funding Announcement DE-FOA-0001865:
Systems Biology of Bioenergy-Relevant Microbes to Enable Production of Next-Generation Biofuels and Bioproducts.
Pre-App required 01/08/2018, 5 PM Eastern [12/17]

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