Genomics:GTL

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Examples of Biological Understanding and Possible Applications Enabled by TMS

Advancing Understanding of Biological Subsystems via Modeling and Simulation

• Regulatory networks: Observations of protein expression and other biomolecules correlated with environmental cues
• Protein interaction networks: Interaction data of several types
• Organization and function of protein and other multimolecular complexes: Homology, interaction, structure, and image data
• Cells: Regulation, metabolism, and biomolecular interactions

Simulation Examples

• Molecular dynamics to visualize the workings of a molecular machine
• Expression of a protein set in a condition that can be tested experimentally to validate a regulatory network
• Combined metabolic pathway, regulatory network, and protein interaction network to explore cell response to environmental changes

Possible Application and Engineering Scenarios Enabled by Advanced Understanding of Microbial Systems

• Elucidate intercellular communication pathways in bacterial communities to understand microbial contributions to ecosystem function, including carbon and nutrient cycling in terrestrial ecosystems
• Understand the roles of cyanobacteria, diatoms, and other microbes in carbon cycling and sequestration